Topical use of anticholinergic drugs could theoretically avoid systemic side effects. However, sufficient absorption through the skin to affect cholinergic nerve endings may be a limiting factor, requiring higher concentrations of drug that may lead to systemic absorption and side effects. Contact sensitization is also .Topical Anticholinergic Reduces Underarm Hyperhidrosis. WASHINGTON, DC An investigational anticholinergic topical gel is safe and effective for the treatment of axillary hyperhidrosis, according to results from a phase 2b study..
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