Topical Anticholinergics

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Topical use of anticholinergic drugs could theoretically avoid systemic side effects. However, sufficient absorption through the skin to affect cholinergic nerve endings may be a limiting factor, requiring higher concentrations of drug that may lead to systemic absorption and side effects.[58] Contact sensitization is also .Topical Anticholinergic Reduces Underarm Hyperhidrosis. WASHINGTON, DC An investigational anticholinergic topical gel is safe and effective for the treatment of axillary hyperhidrosis, according to results from a phase 2b study..