Medical Definition of hydrochloride. : a salt of hydrochloric acid with an organic base used especially as a vehicle for the administration of a drug..Noun. a salt, especially of an alkaloid, formed by the direct union of hydrochloric acid with an organic base that makes the organic constituent more soluble. Origin of hydrochloride. 1820-1830. First recorded in 1820-30; hydro-2+ chloride..In chemistry, a hydrochloride is an acid salt resulting, or regarded as resulting, from the reaction of hydrochloric acid with an organic base e.g. an amine . An archaic alternative name is muriate, derived from hydrochloric acid 's ancient name: muriatic acid..
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