How does hydrochlorothiazide work? A diuretic such as hydrochlorothiazide reduces the overall fluid volume in the body, thereby reducing pressure within blood vessels. Fast facts. Drug schedule: schedule 3. Available as: hydrochlorothiazide is available as tablets. What does it do? lowers blood pressure .Microzide hydrochlorothiazide : "Having gone through a long list of life 's tribulations high BP and all that entails wasn 't surprising. Tried lisinopril several times, still felt general malaise. Went to cardiologist everything checked out. I started taking hctz-after a day I felt great and two months in, still do. Curious now why it works .Missed Dose. If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses..
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